	   SnapGene       ÞtgcatgcctgcaggtcgagatccgggatcgaagaaatgatggtaaatgaaataggaaatcaaggagcatgaaggcaaaagacaaatataagggtcgaacgaaaaataaagtgaaaagtgttgatatgatgtatttggctttgcggcgccgaaaaaacgagtttacgcaattgcacaatcatgctgactctgtggcggacccgcgctcttgccggcccggcgataacgctgggcgtgaggctgtgcccggcggagttttttgcgcctgcattttccaaggtttaccctgcgctaaggggcgagattggagaagcaataagaatgccggttggggttgcgatgatgacgaccacgacaactggtgtcattatttaagttgccgaaagaacctgagtgcatttgcaacatgagtatactagaagaatgagccaagacttgcgagacgcgagtttgccggtggtgcgaacaatagagcgaccatgaccttgaaggtgagacgcgcataaccgctagagtactttgaagaggaaacagcaatagggttgctaccagtataaatagacaggtacatacaacactggaaatggttgtctgtttgagtacgctttcaattcatttgggtgtgcactttattatgttacaatatggaagggaactttacacttctcctatgcacatatattaattaaagtccaatgctagtagagaaggggggtaacacccctccgcgctcttttccgatttttttctaaaccgtggaatatttcggatatccttttgttgtttccgggtgtacaatatggacttcctcttttctggcaaccaaacccatacatcgggattcctataataccttcgttggtctccctaacatgtaggtggcggaggggagatatacaatagaacagataccagacaagacataatgggctaaacaagactacaccaattacactgcctcattgatggtggtacataacgaactaatactgtagccctagacttgatagccatcatcatatcgaagtttcactaccctttttccatttgccatctattgaagtaataataggcgcatgcaacttcttttctttttttttcttttctctctcccccgttgttgtctcaccatatccgcaatgacaaaaaaaatgatggaagacactaaaggaaaaaattaacgacaaagacagcaccaacagatgtcgttgttccagagctgatgaggggtatctcgaagcacacgaaactttttccttccttcattcacgcacactactctctaatgagcaacggtatacggccttccttccagttacttgaatttgaaataaaaaaaagtttgctgtcttgctatcaagtataaatagacctgcaattattaatcttttgtttcctcgtcattgttctcgttccctttcttccttgtttctttttctgcacaatatttcaagctataccaagcatacaatcaactccaagctttgcaaagatggataaagcggaattaattcccgagcctccaaaaaagaagagaaaggtcgaattgggtaccgccgccaattttaatcaaagtgggaatattgctgatagctcattgtccttcactttcactaacagtagcaacggtccgaacctcataacaactcaaacaaattctcaagcgctttcacaaccaattgcctcctctaacgttcatgataacttcatgaataatgaaatcacggctagtaaaattgatgatggtaataattcaaaaccactgtcacctggttggacggaccaaactgcgtataacgcgtttggaatcactacagggatgtttaataccactacaatggatgatgtatataactatctattcgatgatgaagataccccaccaaacccaaaaaaagagatctttaatacgactcactatagggcgagcgccgccatggagtacccatacgacgtaccagattacgctcatatgATGGCTTTCAAGGAAATCGCAATGTTTTCCAGTTTAGTGGTGGTCATCATAAGCTACAATGTACTAGAAAGCAATGCATTAATGATGCAACCATTAATAGACCAAGATTTCTGTGCAGTAAAAGCTAGTTTGTACGAATTGGGAGAGGCTGAGATGAACTTGATGGACGATTCGCAGACATTAAACGACATGCAAAGAGAATATTTTGCTGGAAAAGTTGACTATTCTGCTGTGGAAAGAGCAAGGAATGAACTTAATAAGTCCAAAAACAAGTGGTTCCAAAAAGTTATACAATATCTCAAGGCAACAAATGAATTTGAGCCCACAATCAACTATCAAACCTCAGATCCACAAAAAGTTTACCATCAAATGGATGACTTGGACAATTATAAAGATGCTCTAGATGATATGCATGAAAATATCCTTAAATCAATGTCCCCTACCGTAGCCCAACCTGTTGTAGCATAAggatccatcgagctcgagctgcagatgaatcgtagatactgaaaaaccccgcaagttcacttcaactgtgcatcgtgcaccatctcaatttctttcatttatacatcgttttgccttcttttatgtaactatactcctctaagtttcaatcttggccatgtaacctctgatctatagaattttttaaatgactagaattaatgcccatcttttttttggacctaaattcttcatgaaaatatattacgagggcttattcagaagctttggacttcttcgccagaggtttggtcaagtctccaatcaaggttgtcggcttgtctaccttgccagaaatttacgaaaagatggaaaagggtcaaatcgttggtagatacgttgttgacacttctaaataagcgaatttcttatgatttatgatttttattattaaataagttataaaaaaaataagtgtatacaaattttaaagtgactcttaggttttaaaacgaaaattcttattcttgagtaactctttcctgtaggtcaggttgctttctcaggtatagcatgaggtcgctcttattgaccacacctctaccggccggtcgaaattcccctaccctatgaacatattccattttgtaatttcgtgtcgtttctattatgaatttcatttataaagtttatgtacaaatatcataaaaaaagagaatctttttaagcaaggattttcttaacttcttcggcgacagcatcaccgacttcggtggtactgttggaaccacctaaatcaccagttctgatacctgcatccaaaacctttttaactgcatcttcaatggccttaccttcttcaggcaagttcaatgacaatttcaacatcattgcagcagacaagatagtggcgatagggttgaccttattctttggcaaatctggagcagaaccgtggcatggttcgtacaaaccaaatgcggtgttcttgtctggcaaagaggccaaggacgcagatggcaacaaacccaaggaacctgggataacggaggcttcatcggagatgatatcaccaaacatgttgctggtgattataataccatttaggtgggttgggttcttaactaggatcatggcggcagaatcaatcaattgatgttgaaccttcaatgtaggaaattcgttcttgatggtttcctccacagtttttctccataatcttgaagaggccaaaacattagctttatccaaggaccaaataggcaatggtggctcatgttgtagggccatgaaagcggccattcttgtgattctttgcacttctggaacggtgtattgttcactatcccaagcgacaccatcaccatcgtcttcctttctcttaccaaagtaaatacctcccactaattctctgacaacaacgaagtcagtacctttagcaaattgtggcttgattggagataagtctaaaagagagtcggatgcaaagttacatggtcttaagttggcgtacaattgaagttctttacggatttttagtaaaccttgttcaggtctaacactacctgtaccccatttaggaccacccacagcacctaacaaaacggcatcaaccttcttggaggcttccagcgcctcatctggaagtgggacacctgtagcgtcgatagcagcaccaccaattaaatgattttcgaaatcgaacttgacattggaacgaacatcagaaatagctttaagaaccttaatggcttcggctgtgatttcttgaccaacgtggtcacctggcaaaacgacgatcttcttaggggcagacattagaatggtatatccttgaaatatatatatatattgctgaaatgtaaaaggtaagaaaagttagaaagtaagacgattgctaaccacctattggaaaaaacaataggtccttaaataatattgtcaacttcaagtattgtgatgcaagcatttagtcatgaacgcttctctattctatatgaaaagccggttccggcgctctcacctttcctttttctcccaatttttcagttgaaaaaggtatatgcgtcaggcgacctctgaaattaacaaaaaatttccagtcatcgaatttgattctgtgcgatagcgcccctgtgtgttctcgttatgttgaggaaaaaaataatggttgctaagagattcgaactcttgcatcttacgatacctgagtattcccacagttggggatctcgactctagctagaggatcaattcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgataacttcgtataatgtatgctatacgaagttattaggtctgaagaggagtttacgtccagccaagctagcttggctgcaggtcgagcggccgcgatccggaacccttaatataacttcgtataatgtatgctatacgaagttatcagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcatagctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtctaagaaaccattattatcatgacattaacctataaaaataggcgtatcacgaggccctttcgtctcgcgcgtttcggtgatgacggtgaaaacctctgacacatgcagctcccggagacggtcacagcttgtctgtaagcggatgccgggagcagacaagcccgtcagggcgcgtcagcgggtgttggcgggtgtcggggctggcttaactatgcggcatcagagcagattgtactgagagtgcaccataacgcatttaagcataaacacgcactatgccgttcttctcatgtatatatatatacaggcaacacgcagatataggtgcgacgtgaacagtgagctgtatgtgcgcagctcgcgttgcattttcggaagcgctcgttttcggaaacgctttgaagttcctattccgaagttcctattctctagctagaaagtataggaacttcagagcgcttttgaaaaccaaaagcgctctgaagacgcactttcaaaaaaccaaaaacgcaccggactgtaacgagctactaaaatattgcgaataccgcttccacaaacattgctcaaaagtatctctttgctatatatctctgtgctatatccctatataacctacccatccacctttcgctccttgaacttgcatctaaactcgacctctacattttttatgtttatctctagtattactctttagacaaaaaaattgtagtaagaactattcatagagtgaatcgaaaacaatacgaaaatgtaaacatttcctatacgtagtatatagagacaaaatagaagaaaccgttcataattttctgaccaatgaagaatcatcaacgctatcactttctgttcacaaagtatgcgcaatccacatcggtatagaatataatcggggatgcctttatcttgaaaaaatgcacccgcagcttcgctagtaatcagtaaacgcgggaagtggagtcaggctttttttatggaagagaaaatagacaccaaagtagccttcttctaaccttaacggacctacagtgcaaaaagttatcaagagactgcattatagagcgcacaaaggagaaaaaaagtaatctaagatgctttgttagaaaaatagcgctctcgggatgcatttttgtagaacaaaaaagaagtatagattctttgttggtaaaatagcgctctcgcgttgcatttctgttctgtaaaaatgcagctcagattctttgtttgaaaaattagcgctctcgcgttgcatttttgttttacaaaaatgaagcacagattcttcgttggtaaaatagcgctttcgcgttgcatttctgttctgtaaaaatgcagctcagattctttgtttgaaaaattagcgctctcgcgttgcatttttgttctacaaaatgaagcacagatgcttcgttgct  G½                  ,                                              /   A           '                                         &   '      4      )   %                        &      ,   %            #   +                           !   .   (         $   -         (   #      %   /   8   #   >   ™   I   0   1   @   3   "       &   '   +      7      #   )   6   3   )   $   (   7   $      0   $         !            4               "         /   -             '         4   '         (   ,         2            "            5   +   '      <   ,   &            $   $   +   )   1      ,   -      /   .   Z   D   #   +   H   ,         !          -   ,   #   #      C   )      #                         "               %            -         $         %   A   2   !   !      ,   $            "         %            $      "      A   5      (   +                     ,                +                        &IÄÅÆuÉ„%¡¥'Û)Ñ  ‰Dv'B„å&á¦(% ÐoÚ§æÒ´ Z JiÇÊí
	ÊÏ¢Ü�ï* å 'ž�ƒ
x…»mÔ0¯ú > ú 1rw‘C$Œ˜%É%§ÑÄç„, 5 B…Šôƒ�Þ(ÁˆŸªç
„}¡ß&ëà‹âZ3XÞ&[ì,p	�¨¸ÈØ%  þEÕ.)	Š	P…Ü<n';)ä»Û(ßÓµ Ã  îòZ2	c
–
eX æÀ/UQ gÆÉéjlÆÜxJ³Çh¦£¯UþŽµ‘‚ž§– ( 3ÈÉËÏú
ª{•À~ùHž¸Ýó:gˆÈÁá^  EKHêÈ¦
½
k�
6ËÐKí¯‘ÝQð+  [ [Zß«
î
˜¶ÖL…gøMGä[ÝdAÊ  � À Ù æ ÷ (o.‚cãWQ‹¬¼òq²Ñ.ûí¹Ï°{û H 0äÓ1Woæbºo†Ðvƒ­W”*… ‡ í Ÿ¼¸H„
Ä
�kÌJP@ìn"Õ
Í Ô #
ÒÃ_@y…OšHSeá1<‡ ë sÇF�
¤
´]�>ÊÞ9#ª­ñ�Ò…  +2¶ì¿xühDLz>™&5ö¨úª8Å?b)k… � û †—½ÿT’†7­&­bZxð”ÀA- ? ¨Ö¿ë…¤ô“	™	%†±Kõ@�í5…þè1§_y/  E 4¡æ†Áþ"„ÓùMŽ
;bàŒ €ß',KÄ=-<q2‘âÉãñ4m‹&ÎK Ç A   / 6 c o • |C‘Ü.þ´Âø‰ T	²	t
Ö
ß
è
vÚ3 µÅÎìCx•ábã4µ\³ñ
¹?VªÙ"6Apâ+‡¤  �   >¤õ(ß)­=|«î¤	:
L
@ê‘°•!¬©Áq1ŽÇ  _ €Î‹…Ó_Q¯ì…*~ý¢'+@.ý[8Yzíò Ò!Ä' % ~ QTÃ€°ÄÒÉÌ/2GJµ	NW*	?	H	¡	ä
l›÷=€D¡àÔ˜¶Ï   y Ü ÿzŠìÖ3¢PK	¬	þ
œü†ž(öÀö*ÊÂËòÜ� -âF§^%,Q¶‘!oVÙ¶øå¨6Ö S ‘    j	‹	2
Ýz(<Uq¼ÇÏ)’çù'):^ W¸îïž[fwÖ� âM¤Ç›7  O `/‘–t‡�£fp3		fß÷¾úç Š¼½0i³g´íd2 ¸ ¯!©çv‘-	G
—
cr.ÖÁÂ²�Vm Ä ZÚàXód
ÃY¡^ŽûŒü¼ä„R ¾ ÇòmÇ%ÚÝ�Æy /Èiãe°,�ê?³ m é êa´�T`¯>‹’ƒŸ¨ž¥/ t hkOK§ÌÎ^–Vr½¶C± ñ ˆÊm&Í	Ô	¼¤íêtÿèýRDC—°¦Z ¼iÞRr	�	©	û
•uîEXøh‰¿~X;Á& ) É%ÁÐ+
)
ˆüâwºÁÒE˜^Ÿ¹Þ\z5|GÙZGü�â _ � ' � ™&ÌOþ5Q«©–ÿnu¶úIô4;RÉ³~v¬
�[¯ÂÑ 4VÊ”¡ò9*|;
Z”–:4 v FLvI
X[^¶ëŽ~	¾
÷
ž�­ÌúrTuÛî"Ækd«i›ž+9Â5¾
½Þô3 [ q ° ×  {!Ó?EÊÖhƒRûm‰òERñc ) Ÿ ý ¿P;n’ÍÕ5	õ	
§
l	$)W(°tÔ’š@�Ä{™Òö > ™ % ¹|‚œÉÀ	—Ø7MÑ®e€LÐèöQ_ƒ	 �Þ@,kæôv¦ÿ| »   \ ³Á
·×9óÞêHå\ºÁ jvãà¬
ï
™h	)‡ªN©	¸.p¢ÒËö  L\aB±
É
SÍ-M†¨Þe—^÷P�Õ ±>[ºh	ù.¯B  � Á ø pÜHäƒM£­ð÷üŒ· Ý(	 Ú )O´»ÌØƒd¼Œ¾Só³ï�øîº±™o ç üXñ…Ä´irÒ*Ðy|—þ»ò1 o ® & � É ñÖ/~‡ÔRÄÉ¡½Þì/“A®7”å1•ü²Ì-³{¬ê) g ¦  	 (cž	ñô'içú‡D0ÑÔê¢¥°9@Xï»ê3�´ð ‰ , I ¥ 7�15o]ÍUÈüu¦å¼	LÔXpc@pBMwžíG–‡•Ÿ†µ\%  A 
Šó1¶P	„	Ï	°j£¸2»"��’®`få+OWÀØq¹÷6 t ³  « oŸ§ÖõžÖ	™¬ýv„[T3Ea:Pê}N Ê  µ â î Á?0I…š›	°Q²TóAŠÛínBjo�H…ê2© !û¸ G¬½ê1Ýñ5³
8y#t§a™¨™ø# ˆ ZÈ€¹…
‘
Å
¡�MÍ9K2Ö<Ç1vÖÎƒÑÞxó›i Ò + Ë Ø7­B	•	ºlToË¿Ïà €£âî<cCkå½ØÅÿ¾·Î/‡Ë®ì + Œ ¨  ’ Ñ ByÃ‰ÓHˆPf)2l=œãh ªðŒ$
 
Ò
`Az†ï3›ITÊ×N%…¡uçF  »í�ú	ÄÖ�¦•®S×> Õ ó áöu	T
ÆÒ…ˆâËˆò Y %ˆÃtÈ€‚
ì
wƒ&ÿÓ/¦®î(ù 4 = �À©‰	Od|Û
WŸß:$2W¿ã.º'�ƒ  è2k¥
¼
j—œ©µÆ„¿÷}F®GZò• G ì -GãÒ^Ž?aËŠ«
GRd~Ðú‚¬ì“z†„! Õþ
¾¾ûgEy££
=\=46õ8"©¬ìaw0@,a(jx.  3= £À„øý÷{9
K
�
Õ
?)é2?�ÄÍ 7+²Ã;1«ñU lo�Æ*†£ÃÍ(  ,y‰¯ÑOi¦M	>	G	 	«	ã
ý
ûkš'÷É§Æ(Á95�—Õ R � Î  N ®·í.�•¨æ†¢Weö‰Õ¼ûÆì6c1l l s ‡$ÙÅN`ÿâ•®é~ç>B°üCB¤.Y$ ˜ %U»$NQÀ“*‡á	vÑ3Q[y}4•	Ž Z®û:ŽÐ- ž ü u¾  :Ô4�Ò	¿	
>#–×(DSdÉt!'‚PQc?lª€ˆ�ñ8Á?åób °¹°
,8(©Ý¨®]¡ ×Û}†‚»ÓðÃLö)î‹�6xÿÜË,z«é( f ¥ ( @ 6¦ÕµTû¥ƒ	¯Kió&«ùü!ŽAL‘Óé¡¤Zîe†äé2VM É # À«Ç6é0”	š	�
L84S²ò7;‰ÿá;ijs×½Ð¨¶`ò ‹  ©àïìõt	G‡œ2‡ÖM$(ñ=% < F X $ç‡ÂŽ ¿¨âˆ	»
ë
Nc{V¾|	FQc-¹þ.ë&’¥­‚/  M <~¢­	”§…¡Ð÷úNfx¢=	â
<ú[<3>ÃÔô!6È»`ÂÅ~T5nŒ'i–Ì8 k r t¯ÿ#9M#Œ¸ÄÑ	¾	
¯
=M_"Öà+CRcáÈÐ”�§>P=|37 ûBäò�­9a�Ï# 5Ôª´ÆÚ|èú/�
J�º F�›6à(hL rãÛðUÊ+L È > L j q }®� 8ÏÙöÿ"eù.w‹¡Ð	<	á
ê
^!;Z€ß2B½ÇÏE{“š5EPbÇ_¸Oú¤A*Œ¬8`�ŒË™ K d e p – — ˜ wxyz{’“”34567óôõÃÚabcd-Š¾¿ÎÏ		U	³	´	u
à
é
DEFGHqw789:©D1µr¼ÆíîïDyzžŸ âãäåDO`a™š]^´µ¶·ò78
ù‰Š—¡¢£@tu«#)BCDJKg‹7Bgãäå,^_ˆ‰Š‹¥¦ÈÉÊä  ! " E F a ƒ „ ž Ÿ Â I ! + 0 7 R f *D|•/StµÄÃê%	V	`	C
i
v
×
ò
9IWxÛ.ŽD]ä	4¡¶ÿ–¡æc›29E˜º$vhChæ-§å # G b …   Ã 0 ™ í7£ÝpÛ÷[lÀ	µ	rª?u§Ey¶sðä¶y}ó^‹ W¬[Ú$EL€Þ8Iq1 " , ?¥Eµ›q}±+Êïþ¬ë&	e	D
Q
ÀÜEe
G’·êªr’:sï™»Dˆç	 H † Ä @ 1 S g 9Ò+€öO�Ø'*0T¢*®Ò q}µÚW	w
:J/¼^å5¢ô çcŒ­ÕßªÂÙ%wir<iÈ.¨æc 3 § `ª²–)_àäuŒÅÕ>ï6	à	;
M
j
Ø
XyÜþâóò^l—¢±@duÀ3ed|$ ¡ " 8 ¯ f¼¶Äüa	¥	
·
ó
A�ëï5G–"œFJz2�·Íþ‘  ` š ß Ðš
W™ms‰£ ·(bt/ž-î˜äLÛM\–N& ’Ï<Ëd†¤¬NhqÁçíèr¨FýŠ²,ñ›9àzŒ!\ˆ¡�9JÅ' cŒÔ7ÞÀk¥ø;R° 	É	
ŠZ´×þ¶ùh¡ô_ÅIóZ"Óß"+ �÷î38`ˆÜ\	y	¶	+
†«+@vþzÀAàå\Z·{³~ œIXm­%F·rH & FƒœÄ�ÓÍ,�¶X'	å
Á4máfJH“ëKËOU#7 # - C | RU•¦Þr~Å «²Ê0HK³O­ì+	I	R	¢	E
r
#*²êÝœ},A«“;Xð÷üe¢‰I Å   yg±3Ëðf	
'
(«øp¸Ùs<öE¼t®ôE#  ³ @�¶3ÿ
s@	N	R
F>ƒwts�µš¹á&f±Õè™·
 ‡ Ð ) 2 Ó,‚í+U4~7
­ý_÷6õÁQ|9¨�®ì&x“*_jÄ/v©Óçd 6 V h Ý :õ(M™Î(1Q×f£¯Ó 9æ¶:	†	;BK5‡º3)è‘÷fp+ÅÃbÝ«rJYµzË3 T z �£¥÷ {ùi£+7±~ÛL	X	x
z
ð0Ÿ˜£¥§©«­?�dTVÚxz|~‘jœž«³]É) ›8=P}‹Ù¯¸!QršÖ­	î	
ÿ
S�½æ‚|ËÌóÖàÃÉ€s=T$ ¨ .Ày-;�Æ?Àîô«"_#¯ÚèeÁ¸f¤ßô7l„( mv§«³—`cá¨i7	N
|
36·I�˜½�æ©4bÜ\_js% ¢ 7 ƒ pŒeãù*¥ €ðá	ê	<
Ù
&-Y÷ÿRãÂp›W$m£²6›ç
7QÂíM}»ù8 v µ $ aGïåvÖC_•k
‰
z€Ýò‰’ó:·ùAvÓe¥ìú&× T ’   AûÅ�	¦	Ñ	ò	ô
•Ê­—�¥Ç°(3¾Î0 9 ° óöJ½·ãý	"	b	¸
2l�ë¡ÞìðÄ½/=H†ü#”G{èHëb€-�“œÿf$ Îg?kÝÛ	
3
X
Bº 6Û{)K=½ÐKŠ“Ý*_h‘ ÚúÝ’  k	Z	Œ	¥RµškVšrÈ*¤OYúx;­À¸ XºðŠ¤l¸ ÙÎØ¶¥ÈO! a › X^Ñ›Útœ;\n
Ý
t)ux×„~ŽxÀïÉåƒ]? šŸc,ù™NœV £ à ¹ïXó«g0Ÿ.¡@¬ã»M_‹Ü8N— 0‡¤­Og&©½á1jª�Î‚¢WP Ì 4 P ­ aÐ:~’¥už ºir†)íÂØèú	4	U,àø=sûþ\³òœs}—{"î~:eªÆC À  “6¡?e—Ìgqð	îé©GH!-‹€»:õê5h·‚ëK¼ =’Ì­¶ˆØ÷
Ç¿‹è{¾&´µ]‰3 d?¸Ûàù¯	Ê	~µÏÓÍÚ]mŽ[<Wn �ªÕŠùK&<{ô’		
H
Ø²ï�Â¢(Æ#cd#" °q�”"è8ß$E¦S±.	Ä	˜
[s›úiÃ`Jôo<ÔŸ ¹ üÁlw
d‹ÿ/·×õ³K˜ NÅËà øïo	Ïo,[�‚õ½â/Rus/ [Û"4�¯f©±‰Ýô#X£	Ø	Ä‡“A¤¿ZÁÇÜ¢ÿ_áÍpÚ!�uYG&G…5- ‚áRYaæ		z	,
e
Í
ÉŠŸ¬É€ÿè{�®ÁêBkäZ�æU$†In®¸ÄåIS Å Î9	S]–·	åw–¥]¸ü|´ýJV¼ì ä Hh�
&AƒÉÎä$ ºl€  0A„ó‚Ôí
-�Y‡ž(	1	b
•
æ
ƒ# $ÈÞ%êÝë$' ' fÈGZÅÈÎéÛÞÇª
ù
z5²gKf”ìLÜ9f‡�c@´ÇP�à]  † ¿ /n·"
Â0VnâjVIn?p±-ÏàÌ;V ê …–§ëSÆKó…³Ý¬°?¬Y€“©7„ý>¦4 . D n å!'-¬³LP®íS	£	±	s
ëü:~aŸ´-Bw”a”J<Àá©Ÿâ!3Ñ0Šá J œ Æ ' $ x } SÂëÃ2¡ÈË1I´VJ	1
$+›�µö� UµõpÎñø]  · Vßs�,	F
bÂÞù]ÕŒáh±ŒLf£³ƒ ½ ð l%œÌ	ŽS»ËÍ]_=qsŠ¯¥( € hÝ4ñ8€	
(
P”û)t¨“í¹—tDW÷¾²FØ9u«YFÀ € , u Oz	]¸m{‘Ì}	€L¬ùq­ÏÚVgõ™h�D4½	õ¥ŸÝþ = { ˜ º  iK`²A=âg	À
È
Ré–·-oöÔ Œ N³ËûG„½ÃÈ³Ýïë’@“¶'˜±n²2    ª 	‰�nž4\�Ì 'tO	�	Î	Õ	¢·ð˜?CŒu�ìF_SºD¿×é[p¸ö 5 s ˆ ²  ´ ·>F/„™A	 ¯±Üð	xm Gué¦‚Äþ†˜§šÑ Ù   Ð ò AxÂº�ù	S
Ñ
¥Ñî ­k tÊ›EâgÖ 3 j,i–ÅÚ	`vž‚ö}FYù'y”" ŸÔý-½ƒåVöF	ª	8
J
ü
�Ì7*'Àv+`kÅ0w¢ÂÔ º¿Ø3þu'©Ž¯ÿYú ßî5Ss	‚	®Kïø7Â3R::èiŠí <ªè' e ¤  W #;sç·‡	
<LI*Q=ÂÓóºý{6}¬SÚT•5 * i )­ì¢Œ2RØÂ,k;	_	B
h
8C]p 6�ã0x»þ’™_Æ16DN]øsZfÝHã ` ‚ + ©Nš×&)eã°ÑÔp´P
ý»4ñFéF©¿bq‘yd‹cÞ{Ìý�' Þ öÊcÏ™Mg˜¤:
*
‰Y³ˆÖ‰±ßšµøg, ßÄHl!K[¶GM { x‚œ²M	
")é'@‚ØvõWÊT´%e­ó°"< U š'¤L|P®ÿ68}Õ9	í	
6
y
AR¬¹—¤¦¨ª¬>€ eo{ÄSUqwy{}’›�ª²´S\^ÃÊuÒ, ‚ ou¦øb¤,B”{
ˆ
25¿ñª®ç9·5šaÛÞó	^ëùk%& újÍI>Ü	Y	1 Q´™j…ûJ™¤Æ<‰NGêa�Ÿ¬ù›Üe ¢ Ws›ª:~
Ü
 kƒ+}«ØÈÍ×>U 59}‘>~¬µË¹(ì×ï	T+<G[%©ô�êVB ¿  œÚû#ó®	
}l—nÄÊ;c$ !QŒ°"R•¢	n	Ì
ÎäžÈ¾Ûç�•ÌToÙôá.t»$ … /GgY	ì	@0	!
a
”
©
ø
‚Í#UÇ$é#>¹8ebÆ:ß\ + w äRÁê &,ÇU�ò„Áõû9`\žv´Ü«oÍ6¿àá Ðà › ) J\_·lz�<7	¿
Ç
úQs�¬~f˜gœ,õÓ8ž¿Ü < — ¹ 1 ‹ © Ï MwŽ²Á=EË.Žƒø	Ð
Ÿï®—°ÛïÂÇ²lœ¬j’Ÿ¥ÃÉ¾m…—Öõ4 r ± Ø  ×hÄJt��ŽË&ç¡& £ , r¨¬˜dâoj³^	A
O
7\oHX²ÕP<Eý™¾a�ü05CxcŠ÷k SL- ntwaÔ8	ì	
‡
!(14@~¾&¸P×i„˜ÅMFSÝéò]`òøÛ!dt ¡ |�´"©	}
Û
ÇÚFj
*SªnØók-mA / „ Š �ÀQf+<kÊ6‚ñ÷	`
“
¨
ù–³±7—›Ì‘Åà–�¾Û  ; – š ¸ .   qs�nÖ	ë	
@
Ú
'0[n%G±ÃOisœ;%)/BLölèRñ÷
Ú @ Z þ ÿ  Üäåæç*=BCDEFGLáâj—˜Î�ö	 
=
>
?
[
\
]
^
_
./ZmøEFS¯°*+qrbcnouv“”•–Ó.A…kÓÔÃÓîïð~¼½9 : ? ¶ · D \Ýèú+>HMãoˆ“™¦G‚»Ï!â	æ	
�£ 
Tä,ÔX]dp¤XØwÕ3Ôœ†q|Õ8ŒšÄÔ>ÇN¡úk w # ûUD`�
`u8MúBüké"R`X�‚A�›ÅÕÈõX l Ô + ]bìð§BHƒ�¨×¼Á	Æ	ç	
o
Š
½ÏÙå’¯�q„!¡ÐÔbrÖ?'w§H –é,:?IN}‰”šw"–ã	ý	l
š
{�¤U]˜ÌNÒ-Š“�ÕôfÄY~4;e¸Ñ4
Õf‡¦}loû€¢ADØû   U x } “ ¼ , Þ$HºäèpƒŒæÐÊ�ÞóÐÏM^¥YwÙÃÉxÖ÷ßÏ-9çíõzO üBÂ
av–:Nß˜âê#SYœÆÖ¿Ï²   ] üÑE‘	—	Øô®û,IžBâ4! V´t€§	Ò	ó	õ
9ËÔCëýlæè]¦ž»±¿Â)PŽÐY Õ  Æaž
¸ÍÙaÈƒ“¹Éöð/ m ¬   	‹
š§Ð‚0rˆ‡ý$ªN…ç|�Õ/cì÷.  Ž - : ^K¨¾ nzØ½àþ	#	c	Ç	Þ	
­
¹
ð
¾Úæíñ¾
>¥ÀHéšÓ$×@‰”g, ± kc¾ô÷íw9dž©¯áäè	p
3ì“ßnÙ*«IO7
¢ÑMq£Çúcr(x‘# dñCI„¸äyÂ	m‘¢°ÅiXq¹ÍÑ•>÷"¹Is�Ì�¨# » M-›#—/
™!Tž÷Ü’¹>Eßf”Þˆ§~±Ö1£�£ü y ~  ê –@D	
4
Ê
Ì.‡7<1ÖL˜_QþÛèýE“½ C Í Ú(;@JChŠ•lä	þ	
Y
m
›
f|‚�¼CV^»ÍOÓ7‹”ÎØNgÅZ|Á©mÑiÇ+`iÍm”ÞBÙ V ” ) —]OQSbÏþ~xÞÜ	²
¥.Öõ5VfÒ*ð5L¾‹g"ø‘pü’¡û°î- ª   Óßl\NlWÄ‚ø›sPÚ$y.î# ²»ÃðÑ»Ë	�	´
ô¦#0SÐ¦xÚ/ye°¥VZ<{Á¹  ™%Iåéq�?“[	
‘ Ñ›ú_ZÊòÉ+C!ÐèöÍP _U„çi	ß¶ëh×äµàû:À®  Cà¤$ÚÏnÙåÐ
³ Â ù ýqÝñ‹—;mŠY
Z+·ÃÞÇ×TP DÅYÕwI¥J®ãøT�·ý�Ü�¦ÉÀ Ž Ó Ø ö »Ã
Ñbå„¹OPN™ëñ!u	¸Î)  œ *µ¼ê„’	˜	€
…Jô�ðù4ï¿„^"  ^ b ” {ÍÒýÒÛ^<Þ
uÙ*¯ü´yð>ðp5@ Û PáF]õyØ¿T‘Êæ&C Y_Ùœu�oeq½v�-Ÿ»ú‹Á»²šã è ñÓ	.dìé+¼²Q� ý q	¨	:YDþmµ]{}W% WZµ�›ô	ö
ÕÅçjsÓ^‚úŸšÃ*z˜j¼Ñuó2 Z p ¯ Ö  uÌò†-§¹ÀÑO�õÿ È ºðÕR ¢h­÷ä0”–ýºñ0 n ­  ¤ ò0nôÇb»	h/¯8•?ž2N`Œ³9O´ï|- Ê á  úY×¬¹1SnÊÕ¾ÆÎÚß¢í0Ab�B„ä¼1ÍÝ.wÊ˜÷­ë* h §  ‘ ˆ‹Ÿ
ÕÅ„”ÉR„æ 
 1›¨Ñƒ‰E%1V¾Ïâ«Žíøƒ$ ˆ�®½¥d	Ÿ	Œ
¢
Ô
õ(jè1ˆ«ë¦±:0ðë/4Ž Q � Í  $PÓ)•'s¨ ÜO2Pèk}æ\‡A>£X ¥hòªÒûñ1ˆþK†ÒÕ£Ž#'ÖYdw¼Ïµñ Š % ; ¬“¦L©³Å{¾§Ãá½	®
º
MÕùbzU¹5¦gŸÁêŸ%ïhA J Q 6vŸÎò!osÙöZ`v½Íé		$	ñ
V-¨>CYt¦C\ÞA´q�CN˜x|	ˆ– #(AIŠf«7]€ÇD Á 2 ¦ ® 8Ñ_´€±p^¡»‹*ÉîýÙû5	d	ß	
¶
¿Ûáîòd]ók?tIrîÔØ;‡¶! b‘;26«	¿Vj‡æÿx	È	çqüÿ¿a~�²H—ã›Y‡•!  B ² ”Ýf2ŸªŽrQ	&
q
±3ªào|I+J;ö Nrûd¸s ô7¢<˜Íøh·e™°å…	ï42P��{8§aëÈIX)y, l‹d¿îx:hé	öíÁHˆš"Œ#¼Ž£Ò¤æ6[iPÁƒìLrºø7 u ´ $ @òõâ!	�	Ð	Ú	ñ	W
k¤¹ê”ÃÉ¼Ú.¬“£ÜX¯wg,¿Ù’½ ]Ùò¹?w¿ø ºµ‚^Š ¬  ×öŸ…ù	Æ%¨rz|º–é4¶Í}©»~O Ë  >p“·‰øDJß%zÃ	š±îŒÎÒÌÙ'J\Mb;ž" Í®e¨åW×	Èn‰’£ÀÆ¤­éþjãY�#…UtHFQÃë4 ã e@.è†"U‚±ŸÝmŸoÜkÎÛ†ß� ¶ „Â1J°	0
šø³“ôÔ‹Iàg°¨\K²=2‚% ¼ ï NÜ@á$›|	Ë	“’ìRºÊU\èôCp•n‰3×ªX¤¤ý z    ¹[œú˜œ	¡¶ÐB‹Üîÿ‘?FëE^o žü¹ä¾õ2E	I
Ù269)&uÿþù "ëb¡Ö‹L—
g
Œð/ˆ°Þò¨´MReÜF”$ ›KH­=A|“	

5
è³æ8=zÃ£ˆ™`p$dêøš©±$Rš  «ú'ëm	Ë
ÍãŽ$×Ç¨bºéU¾ " Î ±ãé%D�T/	 
Æ
Ï
ƒP8Œ}Æ[�=ªnaÈÒÏÕß ²]	†
 g}½WÆÔÙOD€ü	`—Äw×j,KA ‰ [rŽÛ)<AKài‡–ÉF�mºå	ÿ	Z
’
Ž¢D®N•Óh:\a×2ËÒ-K„õjpÒ‹ß=•Æ	 ÙœÚ j • 5 •#T9çë‹A§Å	ü	n
™
œ
\_t¼ËÎ‘œÏÃÎL}3ûjÂÈ!W ÏaÎnyô@CW Ó  Ðs–	Ó+ÌØáç¾O’¸Ïá±ï. « ( ½c8cmyx®ß	Ý	¦mØWp¸ÌÐ¤6=M¿æöŒL™ #Æùqˆ � + º Ì Ù'PRýÿ•C	
.
eŒ»Ë×ö6U‘ 0ÀïDlhÆ!Ì°ý0“¢çü¯í, ©  ˜Ò^TÂï’
³
"/êg�ãñd´UÙ#¿Ì  Ò × õ CÄÐÔIO‰X	œ¶t*mÛÍÂäS “ zàé]pºùŠ3%¾=ï ðYp	-\�¸zôit Ç ùÔmŠº	mÔQÅgƒŽƒöQ>ã0�/vî #Ž¼¤Ò¡
Ó
”Ñ§Ûð0JUÎOå"&[†=v, «³5°ª²ÄñŠõY_¼Ìw	µ
§Bay¥BT[¸Ý`j4œf±qâžX'H†6  Ü;ñg�˜ 	Ž	Ù	%
V
õÀ1{‡ÂÈ™z¦ÛW¢ÿvZH¾ \Þ$Vø	Åˆ$í£§ âyËØ€ÿèLG|Âº  ƒZç{	’ �‘ëlÉ[žçŠÛóþ¯DJ šJaãl	f
âç‹¯å§%‡oé÷°¹QT+ âSæê†Ž@\	û	Î
­ÅÊ Ò|ÂCœû[`_ –VÊ,ÑŠÅÎØ?J Ñ&¼rîb‘”
	
-
Ê!é×�ËæT"¯æ Æ Ö ô Xè¹	Ó¹€‰µ·Ì<Áóí :U^—÷v	U
x·ì˜¦iäþáþKW½ Ð`â
…k	áæÈ^‰Úåý‰¯ ÏVWTj	¸	à—Ç†‡ˆØÙ}~¶ãüý;  -¦  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            	                                     	                                                                                                     
                                                                    	                                                                                                              !                                         	                                        	                  	         
            
                   
                                                                                                                     #   &               !   `   ™      2   3         ,   t                                                                                                                                                                                                                                         
                                                                                                                                                                                                                                        	               	                                     
                          	                                        !               	              	      	   
    
       
                                       # &     ! ` ™  2 3   , t   †M  ‡C  ‡U  ‡w  ‹'  �—  –c í 	â; 	Ê-|—âQœJ\Á²6« Õßì
pþ
a»ž	ë´°ŒÑ )Iì%§Ê|Ñ Ãüƒ(•	`czÍñ�É38D´÷i¥)©²·oê$Ò¡
À|_<5� Ä Ãø(²ü ¤
�™&² ² (    ¬ df%ÁˆŒ¯NµU}í8wQÒV
[UM(U m¨•	 !¿gYæ÷†	/
$Äz^ À÷8	@¸M™É
QW“±²YŸ	 D •� £ƒmKõþ™˜"
Ñ„N™;(tî:
i
×
WxÛ¡°I2Îa� ÏM}Ë,«é( f ¥ Oe©:›m“	Ô	týRCmÔ	tRCè–	±§cáN
½�bú8ñ mÔ	tRC"
Š	ô“	‚çO� „4Í 1ä Ü|œ	5
“ìBC¨U� }†ÓQÃ¼.Ë,«é( f ¥ i� Ã ÈŠ	„}K£ZXƒá
Ý+"ƒªyß¤¿#&[úUð�-ay�TžÚ>W›ÚRoÈücíí£ƒÑ BÃÏÓH#’
ÑNâ j&œÑÕNã‹&»�¶ìÅ�ñ mô“	Ô	týRC)ž©p
*
úce©:™Q�ayTÀÌù; &  Ñ 1ƒÒï8óInž%·Ú ð�- e1q©:·U i	Š	'»Æ((9O@·Î\@
[n/BöÀ ÷ o‚P“	ÿž"I2ÎaòÒ£˜FÿN	·°Ž	Æ�
Ÿ ™mŽ	À	Ô	É
Q®w	(t\RCžG¦ B»Ïçž©D	p
‚!7žÜZ**ßW#©mÀ
úc�Þg²¦ ‹ò]ø°ë�9Ñ ñˆŽƒ02–	 œ	Bñˆyß–	ƒO¤ª¿#ö¢*}Ùi ¼¤Uâh€ ñ)•9îßPD	 Š	Ü';»( 	‹	UqÇ)ù:ç�lžUÎÛ\a±
÷�¶ìúÅbk›	ñúAŠÛí�ÑÔ¢êX»´ð ‰ Ã Ô Zòc
Xx øá0A‡Q Ö ô µmÌÁäé³‘‚ž§däm‘¢ÅiX"sÃ Zòc
X øAQñúÑÔ¢X»´ð ‰ ›	AŠÛí�êñ 	Ž	Ù	V
ÂÈÛWv¾% Ã€ÒÌµWä
lº¸ h� ‰›	ñäƒúAMPŠÛíðf�ÑÔ¢ê=X·œ»(´ð ‰  Ö ô ç�lžUÎÛµmÌÁäÏ	j£¸»’®f+Ø	?	=€àÔ˜¶Ï d?ÍÚŽ#Ò”§ÛOå[†=.)	<ßÓµ¤£Xw¿	¦MæŒ � „J¨=åh	ïÛOXào	Ê	~,&¤[1jm¥È¢WsW"„J	
g¦€òMæŒ¨R=” � è}æA£X>·ßÎÒÌÙ\¸îf â7ñ…ÐþÆ ¹	Óí£	¸ Fv^¤	c@ê‘7¶ø.•Ö!­²1ŽÖ S ‘ �òvŸ¹Àšßü\	/
‹
™–÷:0’ªøYßf$/§±.ÆÖî1� Ž Sæê@û	Ê Â V?E æ†Á,-‘{É!ã
)
aˆEhŸÞRm¸ò‹GËZ ¡„ùM; Ä4m‹&Šm
›
^»ÍÎ|Á`ÍmBV 7­¸ vc.Ö²ãah¸‹ËF^¤	@ê‘¶ø•!1ŽÖ S ‘ � ‰äƒMPðf=·œ(>·ßÎÒÌÙè}æA\£X- C «²KO­ìR	¢	r
ê},A“;‰I Å bì�¨ç	o
’¡Ð'wðŠl¶OyÈ ºðÕR ¢h­÷ä0”–ýºñ0 n ­ Ç ùÔmŠº	mÔQÅgƒŽƒöQ>ã0�/vî� Á ø pÜHäƒM£­ð÷üŒ· Ý(	4VÊ”¡ò9*|;
Z”–:À«Ç6é0”	š	�
L84S²ò7;‰ÿá;ijs×½Ð¨¶`ò ‹ � É ñÖ/~‡ÔRÄÉ¡½Þì/“A®7”å1•ü²Ì-³{¬ê) g ¦ žü¹ä¾õ2E	I
Ù269)&uÿþù  j	‹	2
Ýz(<Uq¼ÇÏ)’çù'):^Ô #
ÒÃ_@y…OšHSeá1<‡ Ò × õ CÄÐÔIO‰X	œ¶t*mÛÍÂäS B ² ”Ýf2ŸªŽrQ	&
q
±3ªào|I+J;ö Nrûd¸s‡ Ô í ©ŸàïÀ«Çì6¼¸é0Hõt	”	š	#
„
�
Ä
ÒÃ_�@Lky…Ì8JPG4S‡œ²ò27;@O‰šìÿHSeá;in‡Ö"MjÕá
$(1sÍ×<‡½Ðñ¨¶`ò= ‹  B U { ² ”šÝô'7x‚œ¢¤<Lf|˜Íø2hP®·eŸªÿ68}Ž™°²årÕ9	M	Q	…	í	

&
6
q
y
")AR¬±éï'43ª¹à2o|I—¤¦¨ª¬+>@€‚ØJP�� eov{;{Ä8õSUW§Êö NTar´ëÈûdq¸%IXeswy{}’­›�ª²´ó)S\^y°ÃÊ"uÒšŸc,ù™NœV   ª 	‰�nž4\�Ì 'tO	�	Î	Õ	¢·ð˜?CŒu�ìF_SºD¿×é[p¸ö 5 s ˆ ² § `ª²–)_àäuŒÅÕ>ï6	à	;
M
j
Ø
XyÜþâóò^l—¢±@duÀ3ed|$ ¡ Ñ&¼rîb‘”
	
-
Ê!é×�ËæT"¯æë sÇF�
¤
´]�>ÊÞ9#ª­ñ�Ò…r¨¬˜dâoj³^	A
O
7\oHX²ÕP<Eý™¾a�ü05CxcŠ÷k SL ‚áè2RkÀY«Ç6ašæŸé0		z	”	š	,
e
�
¥
¼
Í
j—œ©µÉŠŸ¬É€ÆÿLè{„�®Áê8Bck¿ä÷Z}�4S²æò,7;F‰ÿ®á;GZiòUjù$†s™×INn®½Ð•œ¨¶`¸ÄåVòIS ‹   ] üÑE‘	—	Øô®û,IžBâ4  4      X   ×         ×���¼Å†	XVA[PM…TufP,\UeHU"†a‰¨:Œ3ÅUÄ©ÍhÝmŽâÌî�Ãs€ÈCˆü0Jª3ãj½B§øÎPF�ÖQcÂ€(Æq÷x"ÚjR�á#j5ØIžEÔz1Ä¨ð‚1u‘1ö¡BÌÙ|äIêA]5�(çÒedt'g]àV
.*s«ZÚ€ˆÞ¦˜§Y�@^§zï˜Ý™¥¥KÖ9$E 	wþó;ªñª«•òš°fú¢Š¼�f¯º®}_ÙÛ¯™gë(.þ]‰0@™ÖEÑŸGQÙ`9]G�õ§xûh`‚v\^YâOäz=¶Ù±J·Ÿê¯j=¹¡Ie�Í�zêºª«ªîïü¢‹·Ù¼ÖUVw•U¥ÇTtß]²ŠôN@&ìSwê¯¯­­ÍÞ{¹a5Âg¯¯Jz¡YUT¨âèæÔ™Y�i¥º¢¯²Ú+²¿«¯¢®ªãušµ9ŸSg[^õ:�Q�•0ZZüO½UEP±h	óÏZ¥µHš8dí¢úÞ­åÒMp¼_¶]{WV»S:·_Z>û—+a—­…–·IV†%–µ_x·à p}^2eÌ¨Þt*Y÷�`a‰™y¹¬a…ÿ}_ÕUº–qíæ@ÄÏ=�'öqÉôiÎÙ†+IÝlÔö·�$¸Š*ƒH¬ÂÑÂÁ3ÍUâ50¿>wÝVqöhvÇÔª½Ti%tç+X¸àuò7¿…éZ§á�¥Wõˆ…cXç5UcŽéRJôDi†TXÓ®‡VþS!f¯Ek×Z¨4QUPŠ-Z¥öÄìN4al‘ž_óR·­x�²7Ûµ««jglª>º¦%æ{îR­nƒØ—î™ª•‡‘icöêª�ùZëaVfœ@é­ê®³Ñ
‚Ô»ÖÔ(°è¹ú=©ÅQ�TVÊ	Ê(w®VS®˜jaªšiYJeUYH™ÕªT‡ºB©Wk¦º^êø�´(êí	“a;¦‡ÝûŸ¯ùþavkÚ¢Z²,«šajÚ™R¦'Vm•UnªSPjº^ºÃ6ß°‚x _~VßJáŸ�½Wê¥ãnµƒéúëCRµ‡ZµÛhÓGQ’d
¦ºƒVàMÈ6
ÉÕõc®‹ƒTCÔÑƒ]_ÔàpC­°F·ÕØ£‚eŸjB€®—�mƒÖÖ†(_­bAZÊè`«ïtª»Ùn…õ]¤êoP}Y`ƒ¶(�=…L=®ˆk¨Þ¸š+y¿Sößlºú»§Õ%gïÞZîuÅ-'êMZ èh”¹TD°cT§`ºRƒ'Z®§ªI_¢´.]çâÚ�}ýÓ~]WµúèëÓ>Û�H~$Ë4ß}iXj±[¡ÚÅÛEdêQ~–°âº\‚ßƒUÇ®�¤X&o¡Y™™š8V%P”U)%hå÷æ�Uu�¾•–hµëRh†56¤¶:îk™…SÂ¼3»~¯ª»õª´¡U	˜ËC¸V—UZ½-±jâ1“?â"»)ŠUVX(å¬^èÛ§øI¯Ý(»ääAµ¬–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�NzÉ–&9œRšBáD§/OS“ ãBÄÃÌoþ–eë&X˜æqJm8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘AÒj	¸Îã…=)úÁU‚Nèo]_|à“*ª*54Ñ§3EUA»QFú†ê¹À.í \UíÊP ¶¦ÕPn·äoªV•XR©[[•&fW ¸t§Ö:[HC~nÓ‹š²¶öJ>ÿ,‰yÆp:}¸?Ò8ÖóýÎßôjm5•ôôðP<LÑH/�z›Ï½½.ih£ÀS‘%$¬ô¥’£5Ê(öŽt6È"Üì² ˜:ÚÓ¼+õÆÔ1)ØoýŠ#US
NúÂûÆÊ-” óH¦ÞØ)ƒMãe®éâØöòQŽ«ˆx!'µõ-®d‰Œ1ñ(î�Ã-g–|ÏvM©TŽÛhrºÀ1W»PnŸ8¡Ò±‰{#^­6êž­ôÊ¸MUÐPÕcÍU@Y@ÇpV(Yížëê­fšÚ›@¦‹¶vj&¤Ueud¼ÍÚ¿ÅR=øråöšm‡i~eVC&ÜCú²ìÌ«aÂ~áÝ�;ðGtè¸”Á�4u?-2Ó(0"À8:^c´M'„HßeÍ©M•ÜÞcÊë¶&fft5ÜÑ™Ç!t„âb3NÌ£j°S;*°W:…+æ¼R¾k¹9&AzÑ3ª}TÎáG7«U_Us|%Äç•fŒYó¯uvŽÕI»¨æfî#™¿™—çö÷êÎú£nW±û�ª¦*näš{©UZ$”^kdH[uœU‰]«ærI™ÕdQ_+eªáõ…Û\æÞ®+uIŒÖ÷l&E™l�©ºV7óN³’[I\ÀR´:ª˜EYõI>ºåú\�#UJmDxÚdLÝPEUInQŽ¢‘U“;°Ú¨‘uU™ê(%Y3»2�«ŠâUcNÑ®¢¡U¤ÎìÊ6ª*�U…7FºÊ	VLêÌ£jâ¸•XÓ´k¨¨Ui3»2�ªŠçU…7F:Ê      µ  	„   Ö  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  (“<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="19" name="MP10" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1975-2436" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q></Feature><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1930-1939" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4705-4721" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4681-4697" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1905-1923" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="2436" maxFusedRunOn="2436" detectionMode="exactProteinMatch"><Segment range="1522-1542" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4774-4795" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2436" maxFusedRunOn="2436" detectionMode="exactProteinMatch"><Segment range="1942-1968" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4729-4735" color="#ffffff" type="standard"/><Segment range="4736-4753" color="#ffffff" type="standard"/><Segment name="-35" range="4754-4759" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="loxP" directionality="2" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4961-4994" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Cre recombinase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Cre-mediated recombination occurs in the 8-bp core sequence (GCATACAT).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="loxP" directionality="2" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4850-4883" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Cre recombinase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Cre-mediated recombination occurs in the 8-bp core sequence (GCATACAT).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6854-6958" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="ADH1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2835-3022" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for the &lt;i&gt;S. cerevisiae&lt;/i&gt; alcohol dehydrogenase 1 (&lt;i&gt;ADH1&lt;/i&gt;) gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="GAL4 activation domain" directionality="1" translationMW="12396.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="768" maxRunOn="2436" maxFusedRunOn="2436"><Segment range="1558-1899" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Saccharomyces cerevisiae GAL4&lt;/i&gt;&amp;nbsp;(truncated)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;activation domain of the GAL4 transcriptional activator&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="LEU2 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4234-4639" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae LEU2&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5234-5822" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ADH1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="771-1476" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for&amp;nbsp;alcohol dehydrogenase 1&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6784" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5993-6784" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6785-6853" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="LEU2" directionality="2" translationMW="38982.00" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3139-4233" color="#ff7f50" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast auxotrophic marker&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae LEU2&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;3-isopropylmalate dehydrogenase, required for leucine biosynthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="2Î¼ ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7240-8404" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast 2Î¼ plasmid origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>18a940d4-24e9-422a-98bb-d398fbbbb0ff</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:22:23">2018.6.14</Created>
<LastModified UTC="7:5:54">2021.6.18</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  2]      ç  4        4���¼Å†	XVA[PM…TufP,\UeHU"†a‰¨:Œ3ÅUÄ©ÍhÝmŽâÌî�Ãs€ÈCˆü0Jª3ãj½B§øÎPF�ÖQcÂ€(Æq÷x"ÚjR�á#j5ØIžEÔz1Ä¨ð‚1u‘1ö¡BÌÙ|äIêA]5�(çÒedt'g]àV
.*s«ZÚ€ˆÞ¦˜§Y�@^§zï˜Ý™¥¥KÖ9$E 	wþó;ªñª«•òš°fú¢Š¼�f¯º®}_ÙÛ¯™gë(.þ]‰0@™ÖEÑŸGQÙ`9]G�õ§xûh`‚v\^YâOäz=¶Ù±J·Ÿê¯j=¹¡Ie�Í�zêºª«ªîïü¢‹·Ù¼ÖUVw•U¥ÇTtß]²ŠôN@&ìSwê¯¯­­ÍÞ{¹a5Âg¯¯Jz¡YUT¨âèæÔ™Y�i¥º¢¯²Ú+²¿«¯¢®ªãušµ9ŸSg[^õ:�Q�•0ZZüO½UEP±h	óÏZ¥µHš8dí¢úÞ­åÒMp¼_¶]{WV»S:·_Z>û—+a—­…–·IV†%–µ_x·à p}^2eÌ¨Þt*Y÷�`a‰™y¹¬a…ÿ}_ÕUº–qíæ@ÄÏ=�'öqÉôiÎÙƒØô…¯lg½±;�[$g…WüÔ­ë^#l�öíjêÚ™Û*�®©‰yžû”«[ ö%û†æEª¥aäZXýºª ~VºØU™§:kE:�ë¬ôB µ.õµ
,:.~�EjqT`UÕ²‚FrŠë•”Å«¦˜j¦šVR™UVR&uj•!î�ªUÅZé®„—º¾$-
:»BdØBÎé¡÷~çÃÂÅkþ˜]šö¨–¬‹*æ˜Z¶¦T©‰Õ›eUD[ª”Ô®—®°ÇM·Ç¬ ž(ß•·Ò¸gãoUú©xÛ­`ú~ºÐÔ­aÖ­vÚ4ÑÔdƒ‡é® Õ¸Eò‚²u}XÂ+¢àÕõ4`×Wõø\ël†mõv(à†™gÚ�€ +¥ä`ÃEµµ¡ŠëX�V²º*ûÝ*®ö[¡D=Wi:›ÔVCX íŠ$aSk¢ê7®Â&ŠÞoÔÇ}·Û.¾®éõIYû÷–»‡]qKIú“Vˆ:e.U,Õ)Ø.” ÉÖ…+©Áª’Wè­—yøŸö¤tß—UÃm~º:ôÏ¶àRß‰2ÆM7ßZV¬VÅèv�qvÑY:”_¥ƒ¬8†®‡× ·àÕqÆë¤Gi	›èVfffŽ‰T%JEIG9}ù U]d/¥eš-zÔš!�M©-…Î»šæaTð¯îß«ê®ýj­(UBf2ÐÇî¥ÕV¯KlZ†¸ŒdÏøˆ®Êb„U–
9Dkº6éÆ~k÷J nÇ¹9mk%¶dâ¯ˆ…h¦ó·Z÷uÙÄðSeH•> �–—·ihÊ3·�Î¯K_‹#Ó†^²e‰Žg¦�¸Q©ËÓÔäè8Ð±0óÁ¥™zÉ–&9œR›N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äPtš‚n3¸áOJ~°UD “ºÃWWß8$Â
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~¹E}¦›aÚ_™U�É·þ¬»3*Âp…_¸wcNüÂÝ:.%0cÀMOË@Ì´ÀŠ°—˜ÃmF‰á7ÙsjSew7˜òºí‰™™�w4fB1È]!8˜ŒÓ³(Ú¬ÎÊ¬Î¡Jù¯¯šîNEI�^´Lê…_U3¸QÍêÕWÕ\ß‰q9åY£|ëÝ]£µRnê9™»ˆæoæeùý½ú³¾…èÛ•ì~çj©Š›¹&žêGUV‰%šÙÅ]gbWjùœ’fDuYWÊÙj¸}aE¶×9·«ŠÝRc5½Û	‘f[ cên…U�üÓ¬ä–ÒW0�-ª¦VG}RO®¹~—çHÕR›Q6™7TUR[”c¨¤UdÎì6ª$]UE&FºŠ	VLîÌ£jâ¸•XÓ´k¨¨Ui3»2�ªŠ§UaMÑ®²‚U“:³(Ú¸®%V4íê*ZLîÌ£j¢¹ÕaMÑŽ²Ž      3  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  'a<?xml version="1.0"?><Features nextValidID="19"><Feature recentID="18" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1930-1939" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="17" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4286-4302" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4262-4278" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1905-1923" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="2052" maxFusedRunOn="2052" detectionMode="exactProteinMatch"><Segment range="1522-1542" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4355-4376" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2052" maxFusedRunOn="2052" detectionMode="exactProteinMatch"><Segment range="1942-1968" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4310-4316" color="#ffffff" type="standard"/><Segment range="4317-4334" color="#ffffff" type="standard"/><Segment name="-35" range="4335-4340" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="loxP" directionality="2" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4542-4575" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Cre recombinase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Cre-mediated recombination occurs in the 8-bp core sequence (GCATACAT).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="loxP" directionality="2" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4431-4464" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Cre recombinase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Cre-mediated recombination occurs in the 8-bp core sequence (GCATACAT).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6435-6539" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="ADH1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2416-2603" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for the &lt;i&gt;S. cerevisiae&lt;/i&gt; alcohol dehydrogenase 1 (&lt;i&gt;ADH1&lt;/i&gt;) gene&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="GAL4 activation domain" directionality="1" translationMW="12396.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="768" maxRunOn="2052" maxFusedRunOn="2052"><Segment range="1558-1899" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Saccharomyces cerevisiae GAL4&lt;/i&gt;&amp;nbsp;(truncated)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;activation domain of the GAL4 transcriptional activator&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="LEU2 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3815-4220" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae LEU2&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4815-5403" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ADH1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="771-1476" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for&amp;nbsp;alcohol dehydrogenase 1&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6365" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5574-6365" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6366-6434" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="LEU2" directionality="2" translationMW="38982.00" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2720-3814" color="#ff7f50" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast auxotrophic marker&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae LEU2&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;3-isopropylmalate dehydrogenase, required for leucine biosynthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="2Î¼ ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6821-7985" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast 2Î¼ plasmid origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>18a940d4-24e9-422a-98bb-d398fbbbb0ff</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:22:23">2018.6.14</Created>
<LastModified UTC="7:4:34">2021.6.18</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  
äý7zXZ  æÖ´F !   t/å£àSh
¢] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÔúéåŸ~éåð£ŒÉ¦yøf¬;ªG�S•ˆOÖRÚ“`¨„pXNº¼/ÿß11,*¯í0$üX1Ê­Çuñ€�ï˜NX‚ÓN"ƒþÑÙuÚ¸ö%¶ZNt,¦CÒšÎK,RÎPdw|‰'$iÒÀe§…¼É†�¦¢Ó±Ô){–ÔT¾	õƒ cæ«‡2ˆRÊ²&e.�£ú‚O
bÛq¼‘Ê�Ø¿%­¼GDì%Ÿœ°u¸Ký}÷9Î Ý±H’IhyImŸ¾y!äô=¬iË\7Þ^4×@„z5Þø“²¤3#ÉŠˆÕjÖf¹’É5�Õ®Inøä3•è==Ãm„O½RkÀý§á2©ðwG%%�èâª?R£^œ÷I÷Îš€BJšîŠáÆÅyýÇD7U!ë¼¥0(5®Ç£P-Ñ¯Wå!`
 ]#’Šû�÷Ls3Caùj«Yª•Ò){�ÚìAk þ‚h[ðÎ	ýƒÂÔœb0û".¥Sç²NÅñÁIK¦lüÈh¹/%6t®H £x‹÷di¨á˜ïëqßÑ²Aã\lúNañ˜sÈ($ÈÒùû¿–{n7üutÅbl·–§YHžÀ(—j©ÞÎ%f°œ?H³¶daQ¯¾0NÃ$:‡ŠÄŸL‹Áû¢¶õõéÜÎ²äpÈð¹£™2´Ï¥”í.Ã<Y×·"ô#ÇhQ¦eºwõ&ß}…ŸèNŸsDw  fûýÀ¦ÎÅµ‚kÌ54Søû‰æÌH«J·÷‘¢µJUŽL´&÷£Ga69+Ä*¢¸°Ì
ž ¸vWöehöœúœÃY6 €9~dúÇW9ÿDõ"t�Î‘�)Ú°$·OŠuèÇ%,KõŽ½P�ìÔî_Pàí‘°ng¸ÝB�ÃÜ\¹àTfÙ9$øA2_�HQ¹/Ä^u
�ˆ$Æ[zLÐïúˆòz4·F{¹è�ÈpL=qVý›.FQ„Cïà�¾C²oèYÉdæÑEíô¢M@€{¢æ<hüùG®®h·ˆNsÀR
:ÃMÒREü›øI0§1ŒTB7ý¡Ç®TLÒ«Ø·*nè"ý¦›šÚð&@7íÉmÖÇ«æ:¸J×f"Ëe [žý¾²8ñ«pp£ÜÚT}ûò¾¤óBŸ¸(ó3î()³:=–Å¿§®é�ãupœöÝÜßXÚ€áð9�ÔÅÅþ�ØÒ¹�aÈÙî™9½,†xßå™8X ¬âÂqÝ("%ÚkÍ…°€¡ŸBowŒàüFVÎÀ³®Ü|¾T¬Åe\.Ä�»h\é>äûxp|:/ßrú
}éË<N8 '=P�’QŠ©ªD•Ñµ€ê…xo–0ð@ã`²q~bÚ¾J™4:�UÏ‰bzXÍ×óÝÍxª�Ÿ�Bde3Åfä3P™ð0‰0]uJ¥’‘F»û<å…íí!È…¨SóÖ‰b¤™Qæ!^ŽÕŽ”D8æúåŒM{¹,tÐúiØð²iº€‚­MøÿáL7ða=Ì“[*}“ye•+¼È@’o¤;ƒ‰¼:Ä­wˆ	Ì2Ëu¸e6�C}êŠÏ"å–´„èP.5ù>•@
¢¶-Šæ€€Œå—�P£¥ÏoÈ
É…çvì@üÑÔ]iòŒ‰{º#LvzÛ³@FZˆhÜ.Wï=æO©JfqFœÊä}N�0D±Kï¾×=×¸zª9ùû[ôn(éÑÒìÎ;|ÐM‘"îŒÿà&u®-@æiù;1_nOºÅ„GÚd%ß@¡¸=BäÞŽ¤éø¾m\Aâî§;Ð‹ô‰�IìéqÂŸÅ¬ÿ)^`'Kõ'i¨ÂÌ6VÝ$è™‹‚IãëñÂLNK;ò°*­€Èöò›`U j+61
ÝÛÃ‘ÅJ¥ý5~Íü`1ŠÐû¹Á«Ž„±XdíÂå�ïçæ×èá>û2(ª¸Ît!mÛŸæF¾ˆIxñ¿;‹b+j9ÀmpMIž¡		?ùï�&$±O½€€°‰)‚ªÉG¦‰pÓÆëiV$~[ÒÒ™Ìœc[ªýÇ{EI½‰ª¬®Æ3t«Å]áF"ªxJÛ?yýÿŠŸ‹ë†õ­.«#ƒ+Ý©Ûq¾ìï ?ÒF”ÓýêÏÀ“(…¼"ð±ÿ½—±lbß’ïélcž3×wêžðþ’æðã°„ÚÞ`g
A˜‰Æ� 2÷e’õ.�ý{qÝs¹y@—qø�ÚÜ4=©HÂ<­ù¶,ïÔpšv¨+ÔÆâ²›~4C­±Ž7gSÖØÉb§úÁQ°�ýK¹:ø·ãðFñÉÞˆ¿Ïþü4ä0y[q
RÕ`&‡ÀÿÞŽ,:Ä ÄÐm«-2YÀ8f(}åN1¶éQü¢”Hdre!�ÅÛøv´jÍmåv{�ÎÅ¶Mz[¯”hÙi8àrx«Oäí•c,ž‹m�`öŠ]/0ñ»×ä8�Ñ€sõÀn#‰D˜Öà„(Xs¾!�ƒä¿CçB‚ñÉÕÝçN2À®˜áÆ9RsêàÓOtg7²òÒ?›%;ëh†œR[ŸL¸Æ‹Hz úÇõïÕÞ3!‚û	_dÌ°-SuÇ‘’D
ŽËfmfŠ@æ{…V3ô–á%u—+Â˜$ØæUåeâbÕ¥•Š¤SZ\P3µ? ê�ˆÏ]&l&EUYb4�=ÚXmö¦v’Be­j_Êì¸ÍÅ‘G8"Ð÷ôíÜß¨Ôök{A–#üÞ¹*¤§h	¤ ‹Æ°à¢D)æ¯(¯ÂªÒ®Šz¹ŽÕ0�BÄìñ´Ñ5aò>Rn­‡�Ž¹É8.§	$šP Éäkð§zGÛ2Œ‹A÷Ã`'‹©7g§v–Q¦è&_ÌãïpJ�m¸`{ïæ¬TÈŽ7ì·lÕ7 Ë[SÓÍö&’Àµ¨Õ  ÞãGÊàáDƒ9Ì	©�p‰QzŠaÝ²0˜QákTÍ¨²d¨ÀM² ž�52â·³ð#CëŸUhÕ–Õé=||.M6E8µ›4J¼]èïj#°–ÿ	"€õ×>w¹Å…0�@À)�å©â©Ÿ„NS§õ°Ô9'�Q­X±ŠØòâßL3]ÀŸ#£þÀÆà
˜úø{ªyŠÔð&?¬¦Ž£Fsÿ‹k\	¾'Zúvì•Ü)ÉƒŠkvsÉ©¹˜Âê¹3@8„øWä=�0Ó1ïÈlÏ™˜àäÇ›°$aõSO˜�Í	íNËZ…*õ-•:ò¸£¹GJø¼5}ç@ûÉ…$Ýzš6õW/zq@ï…{Â9´ø†éïpÚ�ûdH5ÓP™—Ý1’EÍÑµ•î�sÁ£bt„0¡Xº…®€¹Lj]õÙVyì ÁèïØôÄó:=Pý+¸¾¯·¹YqÁXâþ“`ùî…�»U¨Á¤ÁR÷ÊXRY¥ �W!Xf)ÂÐºõàQØyç¦DÑÂ!LàMlSîCàû9x3ôùƒ8�â‰—‘Ž­Ðj�ÅYÀ_úKÿÎˆ½\ž°P     í÷nbÌf¡ ¾é¦  $±Ägû    YZ  O      :®ZTR

BASE      $Ä  xÁA  ƒ°YãxÔ þµ,9œ®ÚHÙF« Ch£Ñ"#£�#TQ@ ÆÈ
ÂabÄ6ÇœNic¡Ê(œI4Ú¬„È	­JYÅÚÚ’$˜!´0LhRÐh‚RCaT¶&`Æª…ƒÚÆØlŒÖhÃQN†à�&0Q5Û VÃ(›­6h`A° am¥ ¬!2aTc*B‚‘€&#E V¡$ÐFÃÚŠ€ÑÌ�hÒ "- ¡¥º˜
Új1	6RrÌ³Éh�‹6 T'¬ÄlMrM”L¨¬¤"$W5-«h#L3X%dmJ41¨* a
šJVUmh@YÒ €
a›E	`µaYªÀVÛ„™‚ÂÖt>h  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  Q     <®ZTR

BASE      &Ê  xÁA  ƒ°YãxÔ þµ,¹å çª�4d[­‚P¡�F‹ŒŒr4ŒPE #+‡‰Ûs:¥�…J8\(£p&Ñh³6 '´*ekkK’`†ÐÂ0¡IA£	JA…QÙš,€«jc³1X£G9R€CšÀDÕlX£l¶6`LØ �ÁR „µ•°"„È„MhP�©	FšŒX…’@kC(F3c4¢Iˆ´€„–jèb*h«Å$ØHÉ1sÌ&£A.FØ P�°K°5É5Q2¡²’Š�\Õ´¬¢F˜f°JÈÚ”h62bPU@Ã4•¬ªÚÐ€²¤@Žm%€Õ†e©2¶Ú&ÌTPØÖt{)«á  <AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>Unmodified</UpstreamModification><DownstreamModification>Unmodified</DownstreamModification></AdditionalSequenceProperties>  <AlignableSequences trimStringency="Medium"><Sequence name="48_GAL4-F_TSS20210625-027-09866_E09" ID="0" sortOrder="0" trimmedRange="3..957"/><Sequence name="49_GAL4-F_TSS20210625-027-09866_F09" ID="1" sortOrder="1" trimmedRange="10..968"/></AlignableSequences>  I‹     ÿ BC N srôe”```pðpáó³2Ô3ãö·²*Í+Î/*IMábÊqqQjZjQj^r*Ã] ÌÁ(6   ‹     ÿ BC ÝíU;ŽAXñI@z¥
®KTé¸TA‘p�½‚->àHDd�#lN°x˜IX‰!­�ú©_Ù]íj»­–ß�'‡_xü,y÷®¼HÿËÕá7¼:¼Éõ}É›dIÞ¾=Ûï�ÎöxÙÿ–ü�d”±…‹å)J…{�‹Ó"B§N–¾T*�JP+õ€n%é2ÆÖhVmœ{«°DF$>Â0AÓ
ãÕ×4b­§Ú+*Ó ÍH.œo”	sç]±Š�ÏZ‡W’â²‘�ZH±Y4b¸ †d¡Þ×ÌM®r
‡Vc€3ëÉ.U&ê\ŽðÚ˜‰‹Jg1>ÅDaM’îÂ¤
ñÞ3¹:; Ö·ÖË¦£¡y¬šß“§MF^Îâ°•ÝÊðÒ6®ÁÝÐ× Í¹ezŠY‹­ð–7ê’mìÍ´f»,f£…fž�¯ˆd1éÀ[ÞÆ,dqªsÐóAtkŒs`X¶´®±]ßíØ±ãÆó§çuÿ/Óÿzoü¿>|ÌõÓe¼__ìç?ŒÿãE&n“kZ+&µ�µ‹ÀCˆ€þµh¹/r�¬3UàøÐ¿ðŽ;þ~ò˜É  ‹     ÿ BC             !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  -"<?xml version="1.0"?><Features nextValidID="20"><Feature recentID="0" name="MP58" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="1975-2442" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MAFKEIAMFSSLVVVIISYNVLESNALMMQPLIDQDFCAVKASLYELGEAEMNLMDDSQTLNDMQREYFAGKVDYSAVERARNELNKSKNKWFQKVIQYLKATNEFEPTINYQTSDPQKVYHQMDDLDNYKDALDDMHENILKSMSPTVAQPVVA*"/></Q></Feature><Feature recentID="1" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1930-1939" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="2" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4711-4727" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="M13 rev" directionality="2" type="primer_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4687-4703" color="#a020f0" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;common sequencing primer, one of multiple similar variants&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1905-1923" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 NLS" directionality="1" translationMW="883.15" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="126" maxRunOn="2442" maxFusedRunOn="2442" detectionMode="exactProteinMatch"><Segment range="1522-1542" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="locus_tag"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;nuclear localization signal of SV40 (simian virus 40) large T antigen&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="protein_id"><V text="&lt;html&gt;&lt;body&gt;&lt;br&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="PKKKRKV"/></Q></Feature><Feature recentID="6" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4780-4801" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="2442" maxFusedRunOn="2442" detectionMode="exactProteinMatch"><Segment range="1942-1968" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="8" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment name="-10" range="4735-4741" color="#ffffff" type="standard"/><Segment range="4742-4759" color="#ffffff" type="standard"/><Segment name="-35" range="4760-4765" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="loxP" directionality="2" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4967-5000" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Cre recombinase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Cre-mediated recombination occurs in the 8-bp core sequence (GCATACAT).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="loxP" directionality="2" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4856-4889" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;Cre recombinase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;Cre-mediated recombination occurs in the 8-bp core sequence (GCATACAT).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="6860-6964" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="ADH1 terminator" type="terminator" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2841-3028" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;transcription terminator for the &lt;i&gt;S. cerevisiae&lt;/i&gt; alcohol dehydrogenase 1 (&lt;i&gt;ADH1&lt;/i&gt;) gene&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="GAL4 activation domain" directionality="1" translationMW="12396.64" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" consecutiveNumberingStartsFrom="768" maxRunOn="2442" maxFusedRunOn="2442"><Segment range="1558-1899" color="#993366" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;Saccharomyces cerevisiae GAL4&lt;/i&gt;&amp;nbsp;(truncated)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;activation domain of the GAL4 transcriptional activator&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="ANFNQSGNIADSSLSFTFTNSSNGPNLITTQTNSQALSQPIASSNVHDNFMNNEITASKIDDGNNSKPLSPGWTDQTAYNAFGITTGMFNTTTMDDVYNYLFDDEDTPPNPKKE"/></Q></Feature><Feature recentID="14" name="LEU2 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4240-4645" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae LEU2&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5240-5828" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="ADH1 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="771-1476" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae ADH1&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for&amp;nbsp;alcohol dehydrogenase 1&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="17" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6790" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5999-6790" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6791-6859" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="18" name="LEU2" directionality="2" translationMW="38982.00" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3145-4239" color="#ff7f50" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;S. cerevisiae LEU2&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast auxotrophic marker&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;3-isopropylmalate dehydrogenase, required for leucine biosynthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPDEALEASKKVDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPIKPQFAKGTDFVVVRELVGGIYFGKRKEDDGDGVAWDSEQYTVPEVQRITRMAAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEVKKILA*"/></Q></Feature><Feature recentID="19" name="2Î¼ ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7246-8410" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;yeast 2Î¼ plasmid origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  —<Notes>
<UUID>b4f6185e-d3d4-4722-aff8-c207a084dc1c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pGADT7-MP58</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:22:23">2018.6.14</Created>
<LastModified UTC="17:29:14">2025.9.3</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      HO  d               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
